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KMID : 0359320010410030299
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Korean Journal of Veterinary Research
2001 Volume.41 No. 3 p.299 ~ p.304
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Involvement of nitric oxide and prostanoid on the endothelium - dependent vasodilatation by acetylcholine in the isolated rabbit renal artery
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김주헌/Kim, Joo Heon
심철수/전석철/Shim, Cheol Soo/Jeon, Seok Cheol
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Abstract
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The effect of the nitric oxide synthase(NOS) inhibitor, N^g-nitro-L-arginine methyl ester (L-NAMW), and the prostanoid synthesis inhibitor, indomethacin, on the vasodilatation produced in response to acetylcholine(Ach) on the isolated rabbit renal artery was exmained. The vasodilatory reponses to Ach(10^-8-3x10^-5M) were completely absent in thevessel which the endothelium had previous been removed. L-NAME(10^5M) significantly reduced the vasodilatory reponse to Ach(10^-8-3x10^-5M). When L-arginine(10^-3M) was also present in the organ bath along with L-NAME(10^-4M) on the vasodilatory reponse to Ach(10^-8-3x10^-5M) was significantly attenuated. Indomethacin (10^-6M) did not significantly affect the vasodilatory responses to Ach (10^-8-3x10^-5M). The inhibition by L-NAME (10^-4M) and indomethacin (10^-5M) on vasodilatory response to Ach was significantly greater than the inhibition due to L-NAME(10^-4M) alone. The present study has established that Ach induce relaxation via and endothelium-dependent mechanism, this relaxation to Ach involves both nitric oxide(NO) and prostanoid in the isolated rabbit renal artery.
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KEYWORD
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endothelium-dependent relaxation, nitric oxide, acetylcholine, indomethacin, renal artery, rabbit
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